Rob is co-creator of the popular Cyanide & Happiness (C&H) webcomic. At the time it was created, Rob was a student at the University of Texas at Dallas.

The comic and animations use stick figure art to present graphic, dark and often surreal humor. It was called one of the 10 best webcomics by a columnist for The Telegraph in 2009, and by 2012, according to Wikipedia, the website was receiving over a million views each day. C&H has won a Streamy Award and has been nominated for an Eisner Award.

C&H has had multiple spinoffs: there have been four seasons of an animated television show called The Cyanide & Happiness Show and two video games are in production. The popular Joking Hazard card game, based on C&H, is wildly popular and has inspired other spinoff games.